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Dr Ioana Slabu and Benedict Bauer with the nanomodified stent. Photo Peter Winandy
30.03.2023

Nanomodified polymerstent: Novel technology for tumour therapy

  • Electromagnetically heatable nanomodified stent for the treatment of hollow organ tumours wins second place at the RWTH Innovation Award

Almost every fourth person who dies of cancer has a hollow organ tumour, for example in the bile duct or in the oesophagus. Such a tumour cannot usually be removed surgically. It is only possible to open the hollow organ for a short time using a stent, i.e. a tubeshaped prosthesis. However, the tumour grows back and penetrates the hollow organ through the stent. Ioana Slabu from the Institute of Applied Medical Technology and Benedict Bauer from the Institut für Textiltechnik of RWTH Aachen University have now developed a novel technology for the therapy of hollow organ tumours, which was awarded second place in the RWTH Innovation Award. This involves a polymerstent that contains magnetic nanoparticles. When electromagnetic fields are applied, these nanoparticles lead to a controlled heating of the stent material and thus of the tumour. Because the tumour reacts much more sensitively to heat than healthy tissue, it is destroyed and the hollow organ remains open. Thus, the stent develops a self-cleaning effect.  

  • Electromagnetically heatable nanomodified stent for the treatment of hollow organ tumours wins second place at the RWTH Innovation Award

Almost every fourth person who dies of cancer has a hollow organ tumour, for example in the bile duct or in the oesophagus. Such a tumour cannot usually be removed surgically. It is only possible to open the hollow organ for a short time using a stent, i.e. a tubeshaped prosthesis. However, the tumour grows back and penetrates the hollow organ through the stent. Ioana Slabu from the Institute of Applied Medical Technology and Benedict Bauer from the Institut für Textiltechnik of RWTH Aachen University have now developed a novel technology for the therapy of hollow organ tumours, which was awarded second place in the RWTH Innovation Award. This involves a polymerstent that contains magnetic nanoparticles. When electromagnetic fields are applied, these nanoparticles lead to a controlled heating of the stent material and thus of the tumour. Because the tumour reacts much more sensitively to heat than healthy tissue, it is destroyed and the hollow organ remains open. Thus, the stent develops a self-cleaning effect.  

Ioana Slabu of the AME explains: "Not only can we drastically reduce treatment costs, but above all we can provide relief for millions of patients worldwide.
 
A manufacturing process and proof of concept for magnetic hyperthermia are already in place. This novel technology has a very high development potential because it can also be used for tumours in other parts of the body such as the prostate, stomach, intestine or urinary bladder or for cardiovascular diseases.  

The AiF/IGF project started under the project title "ProNano" funded by BMWK. Now the approval for the follow-up project "ProNano2" has also been received. The approved project is called: "Validation of the innovation potential of heatable stents for heat-induced treatment of cavity tumours" and is funded by BMBF in course of the VIP+ program. With the Clinic for General, Visceral and Transplantation Surgery of the University Hospital Aachen and the Institute for Technology and Innovation Management at RWTH Aachen University, the consortium is enriched by clinical and economic expertise. Every year, RWTH Aachen University honours particularly innovative university projects with the Innovation Award. Professor Malte Brettel, Prorector for Business and Industry, presented the certificates to four outstanding projects as part of RWTHtransparent.

Source:

ITA – Institut für Textiltechnik of RWTH Aachen University

Photo: Reifenhäuser GmbH & Co. KG Maschinenfabrik
08.09.2022

Ulrich Reifenhäuser receives the Georg Menges Award

Ulrich Reifenhäuser, CSO of the Reifenhäuser Group, was awarded the prestigious Georg Menges Prize 2022 at the 31st International Colloquium on Plastics Technology in Aachen from September 7-8, 2022. The prize recognizes individuals or groups who have rendered outstanding services to the transfer of research results into industrial practice. The sponsors of the award are the Plastics and Rubber section of Germany's Mechanical Engineering Industry Association (VDMA), together with PlasticsEurope Deutschland and the Association of Sponsors of the Institute for Plastics Processing (IKV) in Industry and Craft at RWTH University. The award is traditionally presented every two years during the colloquium organized by the IKV. Ulrich Reifenhäuser is the first businessman to receive the Georg Menges Award.

Ulrich Reifenhäuser, CSO of the Reifenhäuser Group, was awarded the prestigious Georg Menges Prize 2022 at the 31st International Colloquium on Plastics Technology in Aachen from September 7-8, 2022. The prize recognizes individuals or groups who have rendered outstanding services to the transfer of research results into industrial practice. The sponsors of the award are the Plastics and Rubber section of Germany's Mechanical Engineering Industry Association (VDMA), together with PlasticsEurope Deutschland and the Association of Sponsors of the Institute for Plastics Processing (IKV) in Industry and Craft at RWTH University. The award is traditionally presented every two years during the colloquium organized by the IKV. Ulrich Reifenhäuser is the first businessman to receive the Georg Menges Award.

The award was presented by Professor Dr.-Ing. Christian Hopmann, Director of the IKV and Dr.-Ing. Herbert Müller, Chairman of the Board of the IKV Sponsors' Association. In his laudatory speech, Professor Hopmann highlighted Ulrich Reifenhäuser's great and successful commitment to the industry and his tireless search for optimal solutions that are sustainable in the best sense of the word, and praised him as a personality of integrity and integration. "The Georg Menges Prize is awarded for the consistent implementation of research and innovation in industry. The previously described achievements of our prizewinner would certainly have been enough to receive the award but, for the sponsors of the Prize, what was especially important and the key argument for their decision was Ulrich Reifenhäuser’s honorary dedication to the K tradefair," explained Professor Hopmann.

Ulrich Reifenhäuser has been a member of the Reifenhäuser Group management since 1992 and is responsible for international line sales. Together with his brother Bernd Reifenhäuser, he manages the company in the third generation. Ulrich Reifenhäuser has been a board member of the VDMA Plastics and Rubber Machinery Association for more than 25 years and has been its chairman since 2010. In 2020, he was inducted into the Plastics Hall of Fame, as was the award's namesake, and in 2022 he will be co-chairing the world's leading plastics trade fair in Düsseldorf for the seventh time in a row as "President of K show."

Source:

Reifenhäuser GmbH & Co. KG Maschinenfabrik

(c) Kai-Chieh Kuo
17.11.2021

ITA PhD student Kai-Chieh Kuo was awarded Best Master’s Thesis Award of Walter Reiners-Stiftung

Kai-Chieh Kuo, PhD student at the Institut für Textiltechnik (ITA) of RWTH Aachen University, was awarded the German Textile Mechanical Engineering 2021 Best Master's Thesis Award for his master's thesis entitled "Modification of the tube weaving process of fine yarns for the production of woven ultra-low profile stent grafts". The prize is endowed with 3,500€. Peter D. Dornier, Chairman of the Board of the Walter Reiners-Stiftung (Foundation), virtually presented the award on the occasion of the ADD International Textile Conference on 9 November 2021.

Kai-Chieh Kuo, PhD student at the Institut für Textiltechnik (ITA) of RWTH Aachen University, was awarded the German Textile Mechanical Engineering 2021 Best Master's Thesis Award for his master's thesis entitled "Modification of the tube weaving process of fine yarns for the production of woven ultra-low profile stent grafts". The prize is endowed with 3,500€. Peter D. Dornier, Chairman of the Board of the Walter Reiners-Stiftung (Foundation), virtually presented the award on the occasion of the ADD International Textile Conference on 9 November 2021.

Minimally invasive endovascular aortic repair (EVAR) with textile stent-graft systems is nowadays a clinically established therapy procedure for the treatment of abdominal aortic aneurysms (AAA) – pathological bulges of the aorta. Due to the thick profile of the folded stent graft systems, there is currently a high risk of injuring narrowed or highly angulated access vessels from the inside during implantation. Stent graft systems with smaller profiles could provide an improvement, which could overcome complicated access routes through a lower bending stiffness. One possible approach for reducing the system profiles is the use of thin-walled tubular woven fabrics made of ultrafine multifilament yarns (≤20 dtex) as graft material.

Up to now, it has not been possible to process the fine yarns with the required high thread density (>200 threads/cm) and the available weaving technology in order to guarantee sufficient tightness against blood.

In his master's thesis, Kai-Chieh Kuo made high-density tubular weaving of ultra-fine filament yarns possible for the first time by means of suitable modifications to a shuttle loom as well as adaptations in the weaving preparation. In particular, he developed a new innovative reed technology that reduces warp thread friction during the shedding process and thus improves the process stability of the dense tube weaving process of fine yarns.

With the help of the process modification, it was then possible to produce high-density, thin-walled tubular woven fabrics, which were positively evaluated with regard to their suitability for a stent graft. Above all the potential of these tubular fabrics lies in their extremely thin-walled fabric profile, which seals well against blood. By using these new types of tubular fabrics as graft material for stent grafts, the system profile of the folded stent graft system can be reduced without having to compromise the blood tightness of the implant. The technology developed by Mr Kuo is not only applicable to stent graft systems, but also offers great possibilities for use in all other endovascular implants such as trans catheter heart valves, covered stents and small-lumen vascular prostheses.

Frankfurt Fashion Week: hosting the future of fashion © Lottermann and Fuentes
Anita Tillmann and Detlef Braun
02.12.2020

Frankfurt Fashion Week: hosting the future of fashion

  • Looking to the future – Frankfurt Fashion Week is positioning itself with a consistently sustainable agenda and propelling the transformation of a modern, resource-efficient fashion industry.

The Conscious Fashion Campaign (CFC), working in collaboration with the United Nations Office for Partnerships (UNOP), will be the presenting partner and the Sustainable Development Goals (SDGs) will be a prerequisite for all exhibitors by 2023. And the Frankfurt Fashion SDG Summit by CFC is set to become the leading international conference for sustainability in the fashion world. The future of fashion has begun – and its key players will be coming together in Frankfurt am Main from 5-9 July 2021.
 

  • Looking to the future – Frankfurt Fashion Week is positioning itself with a consistently sustainable agenda and propelling the transformation of a modern, resource-efficient fashion industry.

The Conscious Fashion Campaign (CFC), working in collaboration with the United Nations Office for Partnerships (UNOP), will be the presenting partner and the Sustainable Development Goals (SDGs) will be a prerequisite for all exhibitors by 2023. And the Frankfurt Fashion SDG Summit by CFC is set to become the leading international conference for sustainability in the fashion world. The future of fashion has begun – and its key players will be coming together in Frankfurt am Main from 5-9 July 2021.
 
Frankfurt am Main, 2 December 2020. Joining forces to improve the fashion industry: Frankfurt Fashion Week is positioning itself as the host of the future of fashion and actively driving forward the transformation towards a future-oriented, more sustainable fashion and textile industry. All decision-makers looking to instigate this change will be coming together in Frankfurt am Main from 5-9 July 2021. The initiators of Frankfurt Fashion Week – Messe Frankfurt and the Premium Group – have achieved a real coup: Conscious Fashion Campaign, working in collaboration with the United Nations Office for Partnerships, will be the presenting partner. Messe Frankfurt will build on its collaboration with the United Nations Office for Partnerships and establish Frankfurt Fashion week as the platform on which to advance the Sustainable Development Goals and help guide the fashion industry into the 'Decade of Action'.
 
“Frankfurt will play host to the whole world. We are seeing a very positive response indeed,” confirmed Peter Feldmann, Senior Mayor of the City of Frankfurt am Main, at today’s digital press conference, before going on to say: “The fact that the initiators are able to rethink the concept of a Fashion Week in such a way is extremely impressive and proves that the fashion industry is correctly interpreting the signs of the present and future. The time has come for value creation and values to be reconciled. Consistent alignment with the Sustainable Development Goals is an important step in this direction.”
 
“Frankfurt Fashion Week aims to play a crucial role in finding solutions for macrosocial challenges and supporting the goals of international politics such as the European Green Deal. The fashion and textile industries are also expected to be climate-neutral by 2050. If we want to achieve this, we all need to pull together. Frankfurt Fashion Week is inviting all initiators and supporters of sustainable concepts and congresses or shows dedicated to sustainability to meet in Frankfurt, partake in discussions and make tangible decisions for the greater good. We will connect the most relevant players and pave the way for a future-proof fashion and textile industry,” says Detlef Braun, CEO of Messe Frankfurt.
 
“Given its global reach, the fashion industry is uniquely positioned to collaborate and engage on the Sustainable Development Goals, in particular on climate action and responsible production and consumption,” said Annemarie Hou, Acting Executive Director of the United Nations Office for Partnerships. “Frankfurt Fashion Week and the Summit will serve as an important platform for education and engagement of the fashion and textile industry in the Decade of Action,” emphasised Ms Hou.
 
The aim of Frankfurt Fashion Week is for all exhibitors, participants and partners to align with the Sustainable Development Goals by 2023. The SDGs will also be incorporated into all formats of Frankfurt Fashion Week. This will help to make the UN’s sustainability goals visible and tangible for the Fashion Week audience, therefore bringing its claim, goals and specific proposals for implementation to an international opinion-forming fashion and lifestyle community. During a one-day Frankfurt Fashion SDG Summit presented by Conscious Fashion Campaign, topics like gender equality, clean water, climate protection, social justice and their significance for a forward-looking fashion industry will be examined in greater depth. Another point on the sustainability agenda: Frankfurt Fashion Week is launching a Sustainability Award for outstanding, innovative, sustainable design, alongside other categories with a global appeal for the fashion and textile industry.
 
"We are committed to setting the wheels of transformation in motion. Not only does the overall mindset have to fundamentally change; the entire industry also needs to have the courage to be transparent and honest. It’s important to see values and value creation as opportunities rather than contentious. We are doing what we do best: connecting the relevant players at all levels. With its ecosystem, Frankfurt Fashion Week will become the enabler. We are creating a platform that will orchestrate industry-wide change. With this as our inspiration, we are also developing our tradeshow formats from a ‘marketplace of products’ to a ‘marketplace of purpose and ideas’,” explains Anita Tillmann, Managing Partner of the Premium Group.
 
A new start in Frankfurt: In summer 2021 the entire fashion industry will be coming to the metropolis on the Main river to inform themselves, be inspired, discuss, negotiate and celebrate. “There’s a huge need to finally meet in person again, to exchange ideas and be inspired. At the same time, digital tools and formats have become an integral part of the fashion industry,” says Markus Frank, Head of the City of Frankfurt’s Department of Economic Affairs and therefore also responsible for its creative industry. “To implement such a future-oriented, all-encompassing overall concept, Frankfurt’s business and creative scenes offer an almost unique concentration of different expertise with its internationally networked agencies, universities and museums. The city’s multifaceted, high-end club, bar and restaurant scene, diverse hotel industry and internationally renowned retail landscape will become the stage for this. This network will be a key factor in the successful implementation of Frankfurt Fashion Week and the way in which it will expand into the public space as a cultural and social happening.”
 
A number of major publishing houses are also showing their commitment to the new Fashion Week in Frankfurt with conferences, events and awards: Textilwirtschaft, the leading professional fashion journal by the Deutscher Fachverlag publishing house, is moving its traditional meeting of the industry’s top decision-makers – the TW Forum, the presentation of the renowned Forum Award, as well as its subsequent conference – from Heidelberg to Frankfurt’s Palmengarten botanical gardens, and will therefore be kicking off Frankfurt Fashion Week on Sunday evening and Monday morning. The Frankfurter Allgemeine Zeitung will be hosting its traditional fashion party for the first time in Frankfurt and publishing a special edition of its FAZ Magazin on Frankfurt Fashion Week. And the ZEIT publishing group is holding its ‘UNLOCK Style by ZEITmagazin’ conference, which was established in 2014, and the ZEITmagazin Fashion Week party in Frankfurt for the first time and will dedicate the whole new issue of ZEITmagazin Frankfurt to Frankfurt Fashion Week. Condé Nast will also be involved in next summer’s Frankfurt Fashion Week with an exclusive event by GQ. And the Burda publishing house will also be represented with various event formats from its lifestyle and fashion brands.There will also be talks with SHINE  Conventions, the organiser of GLOW, about what a mutual collaboration could look like.
 
Frankfurt Fashion Week is also delighted to have the Fashion Council Germany (FCG) on board.  The FCG is theinstitution when it comes to German fashion design. It promotes designers, is committed to gaining more political relevance and strengthens the international visibility and awareness of German fashion. At Frankfurt Fashion Week, the FCG will contribute selected formats, such as its already established Fireside Chat, and a future-oriented accelerator format to support German designers.
 
“What really impresses me about Fashion Week is the whole networking aspect: the creative industries will meet the financial world and sustainability is the common denominator. The Green Finance Cluster is another project that we could link with Frankfurt Fashion Week in the future. This will provide new inspiration in the fashion industry, which will certainly extend way beyond its own horizon of Frankfurt and Hesse. After a very difficult year for the trade fair industry, the concept is an encouraging breath of fresh air,” sums up Tarek Al-Wazir, Hesse’s Minister of Economics, Energy, Transport and Regional Development and Deputy Minister-President of the state of Hessen.