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Dr Ioana Slabu and Benedict Bauer with the nanomodified stent. Photo Peter Winandy
30.03.2023

Nanomodified polymerstent: Novel technology for tumour therapy

  • Electromagnetically heatable nanomodified stent for the treatment of hollow organ tumours wins second place at the RWTH Innovation Award

Almost every fourth person who dies of cancer has a hollow organ tumour, for example in the bile duct or in the oesophagus. Such a tumour cannot usually be removed surgically. It is only possible to open the hollow organ for a short time using a stent, i.e. a tubeshaped prosthesis. However, the tumour grows back and penetrates the hollow organ through the stent. Ioana Slabu from the Institute of Applied Medical Technology and Benedict Bauer from the Institut für Textiltechnik of RWTH Aachen University have now developed a novel technology for the therapy of hollow organ tumours, which was awarded second place in the RWTH Innovation Award. This involves a polymerstent that contains magnetic nanoparticles. When electromagnetic fields are applied, these nanoparticles lead to a controlled heating of the stent material and thus of the tumour. Because the tumour reacts much more sensitively to heat than healthy tissue, it is destroyed and the hollow organ remains open. Thus, the stent develops a self-cleaning effect.  

  • Electromagnetically heatable nanomodified stent for the treatment of hollow organ tumours wins second place at the RWTH Innovation Award

Almost every fourth person who dies of cancer has a hollow organ tumour, for example in the bile duct or in the oesophagus. Such a tumour cannot usually be removed surgically. It is only possible to open the hollow organ for a short time using a stent, i.e. a tubeshaped prosthesis. However, the tumour grows back and penetrates the hollow organ through the stent. Ioana Slabu from the Institute of Applied Medical Technology and Benedict Bauer from the Institut für Textiltechnik of RWTH Aachen University have now developed a novel technology for the therapy of hollow organ tumours, which was awarded second place in the RWTH Innovation Award. This involves a polymerstent that contains magnetic nanoparticles. When electromagnetic fields are applied, these nanoparticles lead to a controlled heating of the stent material and thus of the tumour. Because the tumour reacts much more sensitively to heat than healthy tissue, it is destroyed and the hollow organ remains open. Thus, the stent develops a self-cleaning effect.  

Ioana Slabu of the AME explains: "Not only can we drastically reduce treatment costs, but above all we can provide relief for millions of patients worldwide.
 
A manufacturing process and proof of concept for magnetic hyperthermia are already in place. This novel technology has a very high development potential because it can also be used for tumours in other parts of the body such as the prostate, stomach, intestine or urinary bladder or for cardiovascular diseases.  

The AiF/IGF project started under the project title "ProNano" funded by BMWK. Now the approval for the follow-up project "ProNano2" has also been received. The approved project is called: "Validation of the innovation potential of heatable stents for heat-induced treatment of cavity tumours" and is funded by BMBF in course of the VIP+ program. With the Clinic for General, Visceral and Transplantation Surgery of the University Hospital Aachen and the Institute for Technology and Innovation Management at RWTH Aachen University, the consortium is enriched by clinical and economic expertise. Every year, RWTH Aachen University honours particularly innovative university projects with the Innovation Award. Professor Malte Brettel, Prorector for Business and Industry, presented the certificates to four outstanding projects as part of RWTHtransparent.

Source:

ITA – Institut für Textiltechnik of RWTH Aachen University

AMAC kooperiert mit ITA (Institut für Textiltechnik der RWTH Aachen und deren ITA GmbH) für die weitere Geschäftsentwicklung im Bereich Composites  © AMAC
fltr: Markus Beckmann, Prof. Thomas Gries, Dr. Michael Effing, Dr. Christoph Greb
19.04.2021

AMAC cooperates with ITA

AMAC cooperates with ITA (Institute for Textile Technology of RWTH Aachen University and their ITA GmbH) for the business development in composites 

As of April 19th, 2021, AMAC is pleased to announce its cooperation with the Institute for Textile Technology, ITA, of RWTH Aachen University and their ITA GmbH. The aim of the cooperation is to strengthen and develop their business activities in composites.

AMAC cooperates with ITA (Institute for Textile Technology of RWTH Aachen University and their ITA GmbH) for the business development in composites 

As of April 19th, 2021, AMAC is pleased to announce its cooperation with the Institute for Textile Technology, ITA, of RWTH Aachen University and their ITA GmbH. The aim of the cooperation is to strengthen and develop their business activities in composites.

ITA, as one of the largest institutes on the campus of the excellence University RWTH Aachen, Germany, develops complete solutions from the manufacturing of the fiber itself over the processing of textile intermediates with thermoplastic and thermoset resins, textile-based part manufacturing, capabilities such as braiding, pultrusion and in-situ impregnation of textile preforms. Top 3 focused industries are transportation and particularly the e-mobility sector, building and construction as well as the wind energy sector. Additionally, ITA GmbH is the partner of the industry in R&D, focusing on 8 business segments, providing technology and knowledge transfer, as well as offering comprehensive solutions along the entire textile value chain.

Prof. Dr. Thomas Gries, Director of ITA, explains the background of the strategic cooperation with focus on composites: „Our long-term experience and unmatched know-how with all aspects of continuous fibers, non-wovens and web-based reinforcements allows us to deliver to the composite manufacturers a complete technology and service offer around the development of technical textiles, from the development of glass and carbon fibers to the textile-based processing of composite parts. In all process steps of our research and developments, we focus on sustainable and recyclable solutions, an efficient cost-performance ratio, the possible use of bio-based materials and the reduction of the CO2 footprint. We are glad to cooperate with Dr. Michael Effing and AMAC in order to benefit from his door-opening network in the composites industry. “

Dr. Michael Effing, Managing Director of AMAC GmbH: „I am very happy to support the ITA to generate innovation thanks to further industrial networking and pre-competitive joint projects. ITA is indeed a one-stop source for composite solutions from the fiber to the cost-efficient manufacturing of final parts. In the context of the Covid-19 impact to the entire industry, it makes sense to bundle forces. Furthermore, ITA, with its long tradition and satisfied customers offers further valuable networking opportunities to the composites industry as well as access to relevant complementary fiber-based excellence and 250 different technologies in their machine-park with an outstanding infrastructure in Aachen.”

Carbon reinforced concrete today: thin-walled curved barrel shells as roof elements at ITA (c) ITA. Carbon reinforced concrete today: thin-walled curved barrel shells as roof elements at ITA
05.06.2020

DFG funds Collaborative Research Centre / Transregio 280 on carbon reinforced concrete

  • Joint proposal of TUD and RWTH Aachen University

On 29 May, the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) decided to fund the Collaborative Research Centre (CRC)/Transregio 280 "Carbon reinforced concrete" at Technische Universität Dresden, short TUD, and RWTH Aachen University with the participation of the Institut für Textiltechnik, short ITA, with 12 million euros over the next four years.

The CRC/Transregio 280 “Design Strategies for Material-Minimised Carbon Reinforced Concrete Structures - Principles of a New Approach to Construction” breaks with the traditional way of designing reinforced concrete plants. The interdependence of reinforcement and matrix is being investigated in depth and a completely new design and construction strategy for building with carbon reinforced concrete is being developed.

  • Joint proposal of TUD and RWTH Aachen University

On 29 May, the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) decided to fund the Collaborative Research Centre (CRC)/Transregio 280 "Carbon reinforced concrete" at Technische Universität Dresden, short TUD, and RWTH Aachen University with the participation of the Institut für Textiltechnik, short ITA, with 12 million euros over the next four years.

The CRC/Transregio 280 “Design Strategies for Material-Minimised Carbon Reinforced Concrete Structures - Principles of a New Approach to Construction” breaks with the traditional way of designing reinforced concrete plants. The interdependence of reinforcement and matrix is being investigated in depth and a completely new design and construction strategy for building with carbon reinforced concrete is being developed.

Carbon reinforced concrete enables completely new design and construction possibilities in the building industry. The reasons for this are its very high strength and the possibility of a very low concrete overlay of only a few millimetres, as carbon, unlike structural steel, does not rust. However, the successful use of the new material, which was awarded the German Future Prize in 2016, requires completely new design and production strategies, which are being investigated in the CRC/Transregio.

Up to now, textile reinforcements have been coated and cured prior to component manufacture. This process is called offline consolidation. These stiff semi-finished products are not suitable for the production of complex components based on new, digital and continuous manufacturing processes (including 3D concrete printing and concrete extrusion). Therefore, ITA is investigating in the sub-project B02 of the CRC/Transregio how forming and consolidation steps are shifted in time by prepreg systems into the concreting process and how they can be applied within the new digital continuous manufacturing processes. In addition to established curing mechanisms, such as by heat or UV radiation, new approaches are also being researched. These new approaches include activation via the alkalinity of the concrete, microwaves and induction

The TUD and RWTH Aachen were awarded the grant on the basis of many years of experience in the research field of textile reinforced concrete. The material textile reinforced concrete was developed in two special research areas at both universities from 1999-2011 and was first fundamentally researched.

19 individual institutes are involved in the CRC/Transregio 280. The spokesman of the TUD is Professor Dr Manfred Curbach, the spokesman of the RWTH is Professor Dr Josef Hegger.

Source:

Institut für Textiltechnik der RWTH Aachen University, ITA

Steuerung eines Industrieroboters per Datenhandschuh Institut für Textiltechnik der RWTH Aachen University
Steuerung eines Industrieroboters per Datenhandschuh
04.04.2017

Wirtschaftlicher Erfolg durch Industrie 4.0: Digital Capability Center in Aachen eröffnet

Der Forschungsstandort Aachen ist um ein einmaliges Angebot reicher: Am Freitag eröffnete mit dem Digital Capability Center (DCC) eine neuartige Lernfabrik mit dem Schwerpunkt Industrie 4.0. In einer realitätsgetreuen Fabrikumgebung erhalten Fach- und Führungskräfte produzierender Unternehmen sowie angehende Ingenieure das Handwerkszeug, um die digitale Transformation im eigenen Unternehmen voranzutreiben. Das Motto: erkunden, ausprobieren, anwenden. Das DCC ist eine Kooperation der Unternehmensberatung McKinsey & Company, des Instituts für Textiltechnik (ITA) der RWTH Aachen University und führenden Technologieunternehmen wie dem Softwareanbieter PTC. Das DCC ist das erste seiner Art weltweit – weitere DCCs werden von McKinsey in diesem Jahr noch in Singapur, Chicago, Peking und Venedig eröffnet.

Der Forschungsstandort Aachen ist um ein einmaliges Angebot reicher: Am Freitag eröffnete mit dem Digital Capability Center (DCC) eine neuartige Lernfabrik mit dem Schwerpunkt Industrie 4.0. In einer realitätsgetreuen Fabrikumgebung erhalten Fach- und Führungskräfte produzierender Unternehmen sowie angehende Ingenieure das Handwerkszeug, um die digitale Transformation im eigenen Unternehmen voranzutreiben. Das Motto: erkunden, ausprobieren, anwenden. Das DCC ist eine Kooperation der Unternehmensberatung McKinsey & Company, des Instituts für Textiltechnik (ITA) der RWTH Aachen University und führenden Technologieunternehmen wie dem Softwareanbieter PTC. Das DCC ist das erste seiner Art weltweit – weitere DCCs werden von McKinsey in diesem Jahr noch in Singapur, Chicago, Peking und Venedig eröffnet.

Die praxisnahen Workshops im DCC helfen Unternehmen, sich dem Thema Industrie 4.0 systematisch und zielgerichtet zu nähern. Sie lernen, wo und wie neueste Technologien entlang der gesamten Wertschöpfungskette eingesetzt werden können – von der ersten Kundenanfrage über die Entwicklung, Produktion und Auslieferung bis zum Servicegeschäft. Aber auch die Anforderungen an das Management sowie die Befähigung der Mitarbeiter und die allgemeine Akzeptanz der mit der Transformation einhergehenden Veränderungen werden thematisiert. Workshop-Teilnehmer erarbeiten konkrete Lösungen für ihre individuelle Problemstellung und erhalten Einblick in zentrale digitale Lösungen und Technologien wie Echtzeit-Diagnosewerkzeuge, Big Data Analytics, prädiktive Instandhaltung, digitales Performancemanagement, 3D-Druck oder kollaborative Roboter.

Source:

Institut für Textiltechnik der RWTH Aachen University