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Dr Ioana Slabu and Benedict Bauer with the nanomodified stent. Photo Peter Winandy
30.03.2023

Nanomodified polymerstent: Novel technology for tumour therapy

  • Electromagnetically heatable nanomodified stent for the treatment of hollow organ tumours wins second place at the RWTH Innovation Award

Almost every fourth person who dies of cancer has a hollow organ tumour, for example in the bile duct or in the oesophagus. Such a tumour cannot usually be removed surgically. It is only possible to open the hollow organ for a short time using a stent, i.e. a tubeshaped prosthesis. However, the tumour grows back and penetrates the hollow organ through the stent. Ioana Slabu from the Institute of Applied Medical Technology and Benedict Bauer from the Institut für Textiltechnik of RWTH Aachen University have now developed a novel technology for the therapy of hollow organ tumours, which was awarded second place in the RWTH Innovation Award. This involves a polymerstent that contains magnetic nanoparticles. When electromagnetic fields are applied, these nanoparticles lead to a controlled heating of the stent material and thus of the tumour. Because the tumour reacts much more sensitively to heat than healthy tissue, it is destroyed and the hollow organ remains open. Thus, the stent develops a self-cleaning effect.  

  • Electromagnetically heatable nanomodified stent for the treatment of hollow organ tumours wins second place at the RWTH Innovation Award

Almost every fourth person who dies of cancer has a hollow organ tumour, for example in the bile duct or in the oesophagus. Such a tumour cannot usually be removed surgically. It is only possible to open the hollow organ for a short time using a stent, i.e. a tubeshaped prosthesis. However, the tumour grows back and penetrates the hollow organ through the stent. Ioana Slabu from the Institute of Applied Medical Technology and Benedict Bauer from the Institut für Textiltechnik of RWTH Aachen University have now developed a novel technology for the therapy of hollow organ tumours, which was awarded second place in the RWTH Innovation Award. This involves a polymerstent that contains magnetic nanoparticles. When electromagnetic fields are applied, these nanoparticles lead to a controlled heating of the stent material and thus of the tumour. Because the tumour reacts much more sensitively to heat than healthy tissue, it is destroyed and the hollow organ remains open. Thus, the stent develops a self-cleaning effect.  

Ioana Slabu of the AME explains: "Not only can we drastically reduce treatment costs, but above all we can provide relief for millions of patients worldwide.
 
A manufacturing process and proof of concept for magnetic hyperthermia are already in place. This novel technology has a very high development potential because it can also be used for tumours in other parts of the body such as the prostate, stomach, intestine or urinary bladder or for cardiovascular diseases.  

The AiF/IGF project started under the project title "ProNano" funded by BMWK. Now the approval for the follow-up project "ProNano2" has also been received. The approved project is called: "Validation of the innovation potential of heatable stents for heat-induced treatment of cavity tumours" and is funded by BMBF in course of the VIP+ program. With the Clinic for General, Visceral and Transplantation Surgery of the University Hospital Aachen and the Institute for Technology and Innovation Management at RWTH Aachen University, the consortium is enriched by clinical and economic expertise. Every year, RWTH Aachen University honours particularly innovative university projects with the Innovation Award. Professor Malte Brettel, Prorector for Business and Industry, presented the certificates to four outstanding projects as part of RWTHtransparent.

Source:

ITA – Institut für Textiltechnik of RWTH Aachen University

(c) ITA
16.12.2021

International Sustainable Aviation and Energy Society Award for Professor Thomas Gries

On 27 November 2021, the Scientific Award for International Sustainable Aviation and Energy Society (SARES Award) was awarded to Professor Dr Thomas Gries from the Institut für Textiltechnik of RWTH Aachen University. The award ceremony took place during the closing ceremony of the International Symposium on Sustainable Aviation (ISSA) in a hybrid format online and simultaneously at Kasetsart University, Bangkok, Thailand.
 
With the award, the committee recognised the ongoing contribution of Pro-fessor Gries and the Institut für Textiltechnik to the digitisation and bio-transformation of the textile sector, as well as the Institute as a place of innovation for sustainable aviation.

On 27 November 2021, the Scientific Award for International Sustainable Aviation and Energy Society (SARES Award) was awarded to Professor Dr Thomas Gries from the Institut für Textiltechnik of RWTH Aachen University. The award ceremony took place during the closing ceremony of the International Symposium on Sustainable Aviation (ISSA) in a hybrid format online and simultaneously at Kasetsart University, Bangkok, Thailand.
 
With the award, the committee recognised the ongoing contribution of Pro-fessor Gries and the Institut für Textiltechnik to the digitisation and bio-transformation of the textile sector, as well as the Institute as a place of innovation for sustainable aviation.

Examples of this include the development of 3D braided ceramic matrix composite components for aircraft engines, which were researched together with partners in a Horizon 2020 project (EU project AllOxITD). The ongoing Chrysomallos research project as another example, funded under the national aeronautics research programme in Germany, aims to develop a completely new and sustainable high-performance insulator for aircraft cabins based on aerogels. These have a significantly lower weight than the glass fibre mats used up to now, while providing the same insulation performance, and solve the problem of the previously high manufacturing costs of aerogels. The aim of the project is to develop an insulation material with reduced density (reduction of more than 20 percent). To this end, a new type of insulation material based on aerogel is to be developed. The basis is an aerogel fleece (0.06 W/mK at 28 kg/m³), which has already been developed as part of a dissertation at the Institut für Textiltechnik of RWTH Aachen University (Mroszczok, J.: 2019).

The aviation industry is one of the fastest growing industries in the world. Due to this fact and its importance for society and the global economy, it needs to make special efforts towards sustainability. The ISSA, an international multi-disciplinary symposium, aims to address current issues in aviation such as improving aircraft fuel efficiency, promoting the use of biofuels, minimising environmental impact, mitigating greenhouse gas emissions and reducing engine and aircraft noise. ^

Through the award, SARES honours scientists and researchers whose work on sustainable aviation issues has made an important contribution at the international level. The selection is based on the scientific publications of the applicant or nominee, the h-index, i.e. the key figure for the worldwide perception of a scientist in professional circles, the project topics and the project results.

New Opportunities for Cellulose Fibres in Replacing Plastics (c) nova-Institut
Nicolas Hark - nova-Institut (DE)
08.12.2021

New Opportunities for Cellulose Fibres in Replacing Plastics

  • Second Session of the International Conference on Cellulose Fibres 2022

Cellulose fibers are a true material miracle as they offer a steadily expanding, broad range of applications. Meanwhile markets are driven by technological developments and policy frameworks, especially bans and restrictions on plastics, as well as an increasing number of sustainability requirements. The  presentations will provide valuable information on the various use-opportunities for cellulosic fibers through a policy overview, a special session on sustainability, recycling and alternative feedstocks, as well as the latest developments in pulp, cellulosic fibers and yarns. In addition, examples of non-wovens, packaging and composites will offer a look beyond the horizon of conventional application fields.

  • Second Session of the International Conference on Cellulose Fibres 2022

Cellulose fibers are a true material miracle as they offer a steadily expanding, broad range of applications. Meanwhile markets are driven by technological developments and policy frameworks, especially bans and restrictions on plastics, as well as an increasing number of sustainability requirements. The  presentations will provide valuable information on the various use-opportunities for cellulosic fibers through a policy overview, a special session on sustainability, recycling and alternative feedstocks, as well as the latest developments in pulp, cellulosic fibers and yarns. In addition, examples of non-wovens, packaging and composites will offer a look beyond the horizon of conventional application fields.

The second session of the conference: "New Opportunities for Cellulose Fibres in Replacing Plastics", will focus on questions such as: "What is the impact of the ban on plastics on single-use products?" and "What are the latest regulatory issues and policy opportunities for cellulose fibres?".  This section presents new opportunities for replacing fossil-based insulating materials with cellulose-based technologies that can be used for a variety of applications, from aerospace to mobility, as well as in construction. For the program just click here.

Speakers of the Session "New Opportunities for Cellulose Fibres in Replacing Plastics":

  • Nicolas Hark - nova-Institut (DE): Opportunities in Policy for Cellulose Fibres
  • Paula Martirez - Stora Enso (SE): Last years Winner Papira® – an Eco-revolution in Foam Packaging
  • Stefanie Schlager - Lenzing (AT): LENZING™ Fibres for Sustainable Single use Products
  • Sascha Schriever - Institut für Textiltechnik der RWTH Aachen University (DE): Cellulose Aerogel Non-wovens – Sustainable Insulators of Tomorrow
(c) Kai-Chieh Kuo
17.11.2021

ITA PhD student Kai-Chieh Kuo was awarded Best Master’s Thesis Award of Walter Reiners-Stiftung

Kai-Chieh Kuo, PhD student at the Institut für Textiltechnik (ITA) of RWTH Aachen University, was awarded the German Textile Mechanical Engineering 2021 Best Master's Thesis Award for his master's thesis entitled "Modification of the tube weaving process of fine yarns for the production of woven ultra-low profile stent grafts". The prize is endowed with 3,500€. Peter D. Dornier, Chairman of the Board of the Walter Reiners-Stiftung (Foundation), virtually presented the award on the occasion of the ADD International Textile Conference on 9 November 2021.

Kai-Chieh Kuo, PhD student at the Institut für Textiltechnik (ITA) of RWTH Aachen University, was awarded the German Textile Mechanical Engineering 2021 Best Master's Thesis Award for his master's thesis entitled "Modification of the tube weaving process of fine yarns for the production of woven ultra-low profile stent grafts". The prize is endowed with 3,500€. Peter D. Dornier, Chairman of the Board of the Walter Reiners-Stiftung (Foundation), virtually presented the award on the occasion of the ADD International Textile Conference on 9 November 2021.

Minimally invasive endovascular aortic repair (EVAR) with textile stent-graft systems is nowadays a clinically established therapy procedure for the treatment of abdominal aortic aneurysms (AAA) – pathological bulges of the aorta. Due to the thick profile of the folded stent graft systems, there is currently a high risk of injuring narrowed or highly angulated access vessels from the inside during implantation. Stent graft systems with smaller profiles could provide an improvement, which could overcome complicated access routes through a lower bending stiffness. One possible approach for reducing the system profiles is the use of thin-walled tubular woven fabrics made of ultrafine multifilament yarns (≤20 dtex) as graft material.

Up to now, it has not been possible to process the fine yarns with the required high thread density (>200 threads/cm) and the available weaving technology in order to guarantee sufficient tightness against blood.

In his master's thesis, Kai-Chieh Kuo made high-density tubular weaving of ultra-fine filament yarns possible for the first time by means of suitable modifications to a shuttle loom as well as adaptations in the weaving preparation. In particular, he developed a new innovative reed technology that reduces warp thread friction during the shedding process and thus improves the process stability of the dense tube weaving process of fine yarns.

With the help of the process modification, it was then possible to produce high-density, thin-walled tubular woven fabrics, which were positively evaluated with regard to their suitability for a stent graft. Above all the potential of these tubular fabrics lies in their extremely thin-walled fabric profile, which seals well against blood. By using these new types of tubular fabrics as graft material for stent grafts, the system profile of the folded stent graft system can be reduced without having to compromise the blood tightness of the implant. The technology developed by Mr Kuo is not only applicable to stent graft systems, but also offers great possibilities for use in all other endovascular implants such as trans catheter heart valves, covered stents and small-lumen vascular prostheses.

Digital Pioneer Awards ceremony at the digitalCHURCH (c) digitalHUB Aachen e.V.; photo: Thomas Langens
Digital Pioneer Awards ceremony at the digitalCHURCH
15.06.2021

ITA Academy GmbH wins Digital Pioneer Award 2021

  • Digital Pioneer Awards ceremony at the digitalCHURCH
  • ITA Academy GmbH was honoured to receive the Digital Pioneer Award at the Digital Summit Event in Aachen on June 09, 2021.

The Digital Pioneer Award is given to companies that drive digitalisation with digital business models, processes or digital products. ITA Academy GmbH was honoured with the Digital Capability Center (DCC) Aachen and its support of companies in their digital transformation.

  • Digital Pioneer Awards ceremony at the digitalCHURCH
  • ITA Academy GmbH was honoured to receive the Digital Pioneer Award at the Digital Summit Event in Aachen on June 09, 2021.

The Digital Pioneer Award is given to companies that drive digitalisation with digital business models, processes or digital products. ITA Academy GmbH was honoured with the Digital Capability Center (DCC) Aachen and its support of companies in their digital transformation.

Using the latest didactic methods, sophisticated solution concepts and state-of-the-art technologies, the DCC Aachen supports people in keeping up with the digital future and becoming pioneers in digital transformation. In order to make innovative solutions such as AI and digital assistance systems tangible, the ITA Academy founded the Digital Capability Center (DCC) Aachen together with McKinsey & Company in 2017. The DCC is a model factory 4.0 in which digital applications are demonstrated and taught using the example of a realistic factory. The DCC thus offers a learning environment for companies in which participants are supported in building up competencies in the field of digital transformation in the form of practical work-shops.

The digital pioneers are to be publicised as best-practice examples in order to sensitize regional SMEs to the topic of digitisation. Around the award of the digital pioneers, the digitalHUB Aachen e.V. rolls out effective marketing activities. The pioneers achieve high visibility through the various planned campaigns and advertising opportunities.